Pediatric transgender medicine is a new field with a lot of questions yet to be answered by science. What is the long-term impact of blocking puberty on a young person’s health? Can practitioners correctly determine which youngsters will still identify as trans when they are adults? Do the psychological assessments contribute to children’s suffering by delaying access to puberty blockers and hormones? Why has the number of teens coming forward to receive transgender medical care, particularly those assigned female at birth, risen so dramatically in recent years?