Biotechnology, Vaccines

Nobel prize in medicine awarded to mRNA pioneers – here’s how their discovery was integral to COVID vaccine development

Dr Katalin Karikó and Dr Drew Weissmanhave been awarded the Nobel Prize for their discoveries into mRNA biology. The pair were the first to discover a way of modifying mRNA that allowed it to successfully be delivered to cells and replicated by them. Their discovery was not only integral to COVID-19 vaccine development, but may also lead to the development of many other therapies – such as vaccines for cancer.

Coronavirus, COVID, Vaccines

CDC Recommends Updated COVID-19 Vaccine for Fall/Winter Virus Season

Vaccination remains the best protection against COVID-19-related hospitalization and death. Vaccination also reduces your chance of suffering the effects of Long COVID, which can develop during or following acute infection and last for an extended duration.  If you have not received a COVID-19 vaccine in the past 2 months, get an updated COVID-19 vaccine to protect yourself this fall and winter.

A colourized microscopic image of a cell infected with the Omicron strain of SARS-CoV-2 virus.
Coronavirus, COVID, Seniors, Vaccines

COVID-19 vaccine boosters are the best defence: Older adults shouldn’t rely on previous infection for immunity

We found that those who had battled the BA.1-2 variant of Omicron in early 2022 had a 30-fold higher risk of contracting the BA.5 variant later in the year. That was exactly the opposite of what we, or anyone, would have predicted. What the findings do tell us is that older adults who have had a previous COVID-19 infection shouldn’t rely on that to protect them against reinfection this fall. To protect against severe illness, keeping booster shots up to date is recommended.

Coronavirus, COVID, Newborn and Infant Health, Pregnancy, Vaccines

COVID-19 vaccination and boosting during pregnancy benefits pregnant people and newborns

The researchers found that pregnant women who received the COVID-19 vaccines generated antibodies against specific types of SARS-CoV-2. These antibodies crossed the placenta and were also found in the cord blood of vaccinated participants. This likely conferred some protection in the newborns against infection immediately after birth—a critical time when they are vulnerable to severe COVID-19 disease but are too young to be vaccinated.

Cancer, Drugs, Vaccines

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.

The current explanation scientists have as to why T cells fail to eliminate cancer cells is because they become “exhausted.” The idea is that T cells initially function well when they first face off against cancer cells, but gradually lose their ability to kill the cancer cells after repeated encounters.